Evidence map›Paper›PMID 42294716›Full record

ArticleMicrobiology spectrum2026

Contrasts and similarities in the transcriptomic response to antimicrobial coinage metals in

Daniel A Salazar-Alemán, Ashley McGibbon, Raymond J Turner

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel A Salazar-AlemánDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.ORCID 0009-0002-6617-302X
Ashley McGibbonDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Raymond J TurnerDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-9263-0776

Funding

Natural Sciences and Engineering Research Council of Canada
6 · The paper itself

Abstract

With the rise of resistance to last-resort antibiotics, metal-based antimicrobials have re-emerged as an alternative to prevent and manage infections. The group 11 metals (copper, silver, gold), historically known for their usage in coins, have demonstrated promising bactericidal activity. Despite their efficiency, we do not have a complete understanding of how bacteria are eradicated by metal ions and how they respond to metal-induced stress. Additionally, most studies in the field focus on the physiological response to acute toxicity, often overlooking longer exposure models. We used RNA-seq profiling to understand the

Indexed as

Anti-Bacterial AgentsEscherichia coliMetalsTranscriptomeCopperEscherichia coli ProteinsGene Expression ProfilingGene Expression Regulation, BacterialGoldSilverStress, PhysiologicalAnti-Bacterial AgentsCopperEscherichia coli ProteinsGoldMetalsSilverantimicrobial tolerancecell envelopecoppergoldiron metabolismmetal-based antimicrobialsmetal effluxmetal resistancesilverthiol metabolismtranscriptomicszinc import

Identifiers

PMID42294716
PMCPMC13339815

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.