Evidence map›Paper›PMID 42294683›Full record

ArticlemBio2026

La Crosse virus, but not Jamestown Canyon virus, is dependent on the host translation termination factor eRF1 due to changes in the nonstructural protein NSm.

Kaeri M Medina, Sarah Dysinger, Rachel M Braun, Swechha M Pokharel, Trevor Griesman, David C Schultz, Paul Bates, Sara Cherry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaeri M MedinaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3997-2774
Sarah DysingerDepartment of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Rachel M BraunDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Swechha M PokharelDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Trevor GriesmanDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David C SchultzDepartment of Biochemistry and Biophysics, High Throughput Screening Core University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Paul BatesDepartment of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3918-5976
Sara CherryDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3956-6610

Funding

Targeting druggable coronavirus proteinsU19AI171443 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SUMIT K CHANDA, Arnab Kumar Chatterjee · 2022 to 2026
$101.4M
Modeling Zika virus pathogenesis and potential intervention during neural development using a human brain organoid systemU19AI131130 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2017 to 2021
$7.7M
The role of pattern recognition and autophagy in innate anti-bunyaviral immunityR01AI150246 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2019 to 2023
$3.5M
Defining the functional interface between the ER and flavivirusesR01AI140539 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA, DIAMOND, MICHAEL S · 2018 to 2022
$3.0M
Elucidating the functional roles of long noncoding RNAs in Chikungunya virus infectionR21AI151882 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA · 2020 to 2021
$446k
NIAID NIH HHS R01 AI140539NIAID NIH HHS R01 AI150246NIAID NIH HHS R21 AI151882NIAID NIH HHS U19 AI131130NIAID NIH HHS U19 AI171443
6 · The paper itself

Abstract

Bunyaviruses are a class of segmented, negative-sense RNA viruses that are transmitted by arthropod and rodent vectors. Members of the IMPORTANCE: The California Serogroup (CSG) orthobunyavirus La Crosse virus (LACV) is the leading cause of arboviral pediatric encephalitis in the United States. Since there are no vaccines or therapeutics to treat LACV, we set out to identify host factors that promote infection as potential therapeutic targets. We found that host translation termination factor eRF1 is required for LACV infection and expected that this would be required for all bunyaviruses. While closely related CSG viruses were also dependent on eRF1, we found that eRF1 is dispensable for distantly related bunyaviruses. Surprisingly, Jamestown Canyon virus, another CSG virus, also does not depend on eRF1. This allowed us to use genetics to discover that the NSm protein sensitizes LACV to eRF1. This may represent a unique target for the treatment of LACV.

Indexed as

Encephalitis Virus, CaliforniaHost-Pathogen InteractionsLa Crosse virusPeptide Termination FactorsViral Nonstructural ProteinsAnimalsHumansVirus ReplicationETF1 protein, humanPeptide Termination FactorsViral Nonstructural Proteinsantiviralbunyaviruscalifornia serogrouptranslation

Identifiers

PMID42294683
PMCPMC13343935

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.