Observational studyAntimicrobial agents and chemotherapy2026
Population pharmacokinetics of vancomycin in serum and cerebrospinal fluid: variability in cerebrospinal fluid concentrations despite targeted serum exposure.
Observational study in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Vancomycin is a key component of empirical therapy for central nervous system (CNS) infections, yet dosing is guided by systemic pharmacokinetic/pharmacodynamic (PK/PD) targets that may not reflect drug exposure at the site of infection. Cerebrospinal fluid (CSF) penetration is variable, and the relationship between serum and CSF concentrations remains poorly defined. This study aimed to develop a population pharmacokinetic model simultaneously describing vancomycin concentrations in serum and CSF using real-world therapeutic drug monitoring (TDM) data and to characterize the relationship between systemic and CSF exposure. A retrospective observational study was conducted in adult neurosurgical patients (
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