ArticleAntimicrobial agents and chemotherapy2026
Ethionamide versus ethambutol-containing first-line regimens for TB meningitis.
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Medha Singh, Madelynn Shambles, Charles A Peloquin, Sanjay K Jain
Abstract read
In one paragraphArticle in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Xueyi ChenCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-1574-7759 Carlos E Ruiz-GonzalezCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yuderleys Masias-LeonCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Medha SinghCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Madelynn ShamblesCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Charles A PeloquinInfectious Disease Pharmacokinetics Laboratory, Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, Florida, USA.
Sanjay K JainCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-9620-7070 Funding
Preclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0MMeasuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET ImagingR01AI153349 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$3.8MPro-apoptotic Drugs as Host-Directed Treatments for Pulmonary Tuberculosis”R01AI190038 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sanjay K Jain · 2025 to 2026
$1.6MPro-apoptotic Drugs as Host-Directed Treatments for Pulmonary TuberculosisR56AI179012 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2024 to 2024
$818kNIAID NIH HHS R01 AI145435NIAID NIH HHS R01 AI153349NIAID NIH HHS R01 AI190038NIAID NIH HHS R56 AI179012NIH HHS R01-AI145435-A1, R01-AI153349, R56-AI179012-A1, R01-AI190038
6 · The paper itselfAbstract
Ethionamide has emerged as an alternative to ethambutol for the treatment of tuberculous meningitis (TB meningitis). Here, we show that ethionamide- and ethambutol-containing first-line TB regimens achieved similar bactericidal activities in brain tissues and reduction in neuroinflammation in a mouse model of TB meningitis. However, ethionamide, but not ethambutol, achieves brain concentrations above the minimum inhibitory concentration for
Indexed as
Antitubercular AgentsEthambutolEthionamideMycobacterium tuberculosisTuberculosis, MeningealAnimalsBrainFemaleMiceMicrobial Sensitivity TestsAntitubercular AgentsEthambutolEthionamidechemotherapyethambutolethionamidetuberculosistuberculous meningitis
Identifiers
PMID42294653
PMCPMC13336335
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