Evidence map›Paper›PMID 42294630›Full record

ArticleInfection and immunity2026

The diabetic wound microenvironment drives emergence and maintenance of CovRS variants in group B

Rebecca A Keogh, Alyx M Job, Luke R Joyce, Madeline S Akbari, Amber Nguyen, Jeffrey S Kavanaugh, Alexander R Horswill, Kelly S Doran

Abstract read
In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecca A KeoghDepartment of Immunology and Microbiology, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0001-8376-2307
Alyx M JobDepartment of Immunology and Microbiology, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0003-3210-2768
Luke R JoyceDepartment of Immunology and Microbiology, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0002-9346-671X
Madeline S AkbariDepartment of Immunology and Microbiology, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0001-6706-5704
Amber NguyenDepartment of Immunology and Microbiology, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0003-2768-8143
Jeffrey S KavanaughDepartment of Immunology and Microbiology, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0002-3876-4001
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0002-5568-0096
Kelly S DoranDepartment of Immunology and Microbiology, University of Colorado Anschutz, Aurora, Colorado, USA.ORCID 0000-0003-4232-6837

Funding

Roles of novel cationic lipids in bacterial pathogenesisR01AI178692 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI Kelly S Doran, Ziqiang Guan · 2023 to 2026
$2.6M
Determinants of polymicrobial diabetic wound infectionsR21AI171853 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S, HORSWILL, ALEXANDER R · 2023 to 2024
$428k
The Diabetic Wound Environment Shapes Group B Streptococcal PathogenesisK99AI180373 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEOGH, REBECCA · 2024 to 2025
$184k
The Role of the Group B Streptococcus Type VII Secretion System in Polymicrobial EnvironmentsF31AI183560 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Alyx M Job · 2025 to 2026
$77k
Mechanisms of Group B Streptococcal Pathogenesis in the Diabetic WoundF32AI172126 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEOGH, REBECCA · 2023 to 2023
$70k
Host-pathogen interactions during GBS diabetic wound infectionsF31AI178881 · NIAID · UNIVERSITY OF COLORADO DENVER · PI AKBARI, MADELINE SOHAYLA · 2024 to 2025
$51k
American Heart Association 23POST1013835National Institute of Allergy and Infectious Diseases F31AI178881National Institute of Allergy and Infectious Diseases F31AI183560National Institute of Allergy and Infectious Diseases F32AI172126National Institute of Allergy and Infectious Diseases K99AI180373-02National Institute of Allergy and Infectious Diseases R01AI178692National Institute of Allergy and Infectious Diseases R21AI171853NIAID NIH HHS F31 AI178881NIAID NIH HHS F31 AI183560NIAID NIH HHS F32 AI172126NIAID NIH HHS K99 AI180373NIAID NIH HHS R01 AI178692NIAID NIH HHS R21 AI171853
6 · The paper itself

Abstract

Diabetic wounds are often infected with microbes, which perpetuate inflammation, and stall wound healing. The bacterium Group B

Indexed as

Bacterial ProteinsDiabetes ComplicationsStreptococcal InfectionsStreptococcus agalactiaeWound InfectionAnimalsDisease Models, AnimalFemaleMiceMutationVirulenceBacterial Proteinsdiabetic woundsgroup B Streptococcusinflammationmicrobial evolutionselection

Identifiers

PMID42294630
PMCPMC13367057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.