Evidence map›Paper›PMID 42294626›Full record

ArticlemSphere2026

From gene detection to resistome ecology: targeted hybrid capture in AMR surveillance.

Giulia Santarelli, Barbara Fiori, Cataldo Maria Mannavola, Roberto Rosato, Giordana Cafaro, Francesca Romana Monzo, Maurizio Sanguinetti, Flavio De Maio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giulia Santarelli *Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Barbara Fiori *Microbiology Laboratory Unit; Department of Laboratory and Hematologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, Rome, Italy.
Cataldo Maria MannavolaDepartment of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Roberto RosatoDepartment of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Giordana CafaroMicrobiology Laboratory Unit; Department of Laboratory and Hematologic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, Rome, Italy.
Francesca Romana MonzoMicrobiota Analysis & Microbial WGS Research Core Facility, GSTeP, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, Rome, Italy.
Maurizio Sanguinetti *Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.ORCID 0000-0002-9780-7059
Flavio De Maio *Microbiota Analysis & Microbial WGS Research Core Facility, GSTeP, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, Rome, Italy.ORCID 0000-0002-4744-9820

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) PE00000007 INF-ACT
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) surveillance requires approaches capable of capturing the full resistome beyond culture-based and targeted molecular diagnostics. Here, we compared a commercial real-time PCR assay for carbapenemase detection with a targeted hybrid capture next-generation sequencing (xHYB) approach for comprehensive antimicrobial resistance gene (ARG) profiling in rectal swab samples. The xHYB panel showed high concordance with PCR for

Indexed as

BacteriaDrug Resistance, BacterialHigh-Throughput Nucleotide SequencingAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesGenes, BacterialHumansReal-Time Polymerase Chain ReactionRectumSensitivity and SpecificityAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasescarbapenemasecarbapenemase genesgut resistometargeted hybrid capture next-generation sequencing

Identifiers

PMID42294626
PMCPMC13410987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.