Evidence map›Paper›PMID 42294622›Full record

ArticlemSphere2026

Kiss and spit metabolomics highlight the role of host purine metabolism during pathogen infection.

Gina M Gallego-Lopez, William J Olson, Andres M Tibabuzo-Perdomo, David Stevenson, Daniel Amador-Noguez, Grant Lawrence, James W Leahy, Emmanuel Contreras Guzman, Melissa C Skala, Laura J Knoll

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Metabolic changes to host cells withbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gina M Gallego-LopezMorgridge Institute for Research, Madison, Wisconsin, USA.ORCID 0000-0001-7872-5595
William J OlsonDepartment of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA.
Andres M Tibabuzo-PerdomoMorgridge Institute for Research, Madison, Wisconsin, USA.ORCID 0000-0002-1260-6902
David StevensonDepartment of Bacteriology, University of Wisconsin, Madison, Wisconsin, USA.
Daniel Amador-NoguezDepartment of Bacteriology, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0002-3568-3070
Grant LawrenceDepartment of Chemistry, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-9465-7833
James W LeahyDepartment of Chemistry, University of South Florida, Tampa, Florida, USA.ORCID 0000-0003-3647-4489
Emmanuel Contreras GuzmanMorgridge Institute for Research, Madison, Wisconsin, USA.ORCID 0000-0002-1929-3961
Melissa C SkalaMorgridge Institute for Research, Madison, Wisconsin, USA.ORCID 0000-0002-6320-7637
Laura J KnollDepartment of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0002-9362-8088

Funding

Functional optical imaging for rapid, label-free predictions of treatment response and clonal evolution in patient-derived cancer organoidsR01CA272855 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI Dustin A Deming, Melissa Caroline Skala · 2023 to 2026
$3.1M
Sexual Development of Toxoplasma in Feline Intestinal OrganoidsR01AI144016 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KNOLL, LAURA J · 2019 to 2023
$1.9M
Morgridge Institute for Resesarch Postdoctoral FellowshipNational Institute of Allergy and Infectious Diseases R01AI144016NCI NIH HHS 3R01CA272855-02S1NCI NIH HHS R01 CA272855NCI NIH HHS R01CA272855NIAID NIH HHS R01 AI144016
6 · The paper itself

Abstract

Intracellular bacteria and protists rely on the host cell to supply many metabolites, but the mechanisms through which pathogens manipulate host metabolism to their benefit are not understood. Here, we demonstrate that when the obligate intracellular parasite

Indexed as

Host-Pathogen InteractionsMetabolomicsPurinesToxoplasmaToxoplasmosisAnimalsHumansPentose Phosphate PathwaypurinePurinescN-II enzymehost–pathogen interactionmetabolomicspurinesToxoplasma gondii

Identifiers

PMID42294622
PMCPMC13410994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.