ReviewExpert reviews in molecular medicine2026
Two Decades of Therapeutic Trials in Supratentorial Intracerebral Haemorrhage: Lessons from Failure and Success.
Review in Expert reviews in molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundSpontaneous intracerebral hemorrhage (sICH) remains associated with high mortality and long-term disability worldwide. Since the publication of the Surgical Trial in Intracerebral Haemorrhage (STICH) in 2005, numerous randomized controlled trials have evaluated surgical, pharmacological, and physiological interventions, yet most have not demonstrated consistent improvements in functional outcomes.
methodsWe critically reviewed major randomized controlled trials and influential studies of acute sICH treatment published over the past two decades, with particular attention to surgical strategies, physiological and pharmacological interventions, treatment timing, patient selection, and sex-related biological heterogeneity.
resultsMost conventional surgical and single-target medical interventions yielded neutral or modest results. Recent trials suggest that carefully selected surgery, early intervention, and bundled protocolized care may provide greater benefit. However, optimal treatment timing and sex-specific biological differences remain insufficiently investigated.
conclusionsFurther progress in acute sICH treatment will require time-sensitive, mechanism-informed, anatomically tailored, and sex-aware multimodal treatment strategies rather than isolated interventions.
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