ArticleDiagnostic cytopathology2026
Diagnostic Accuracy of USG/CT-Guided FNAC With Rapid On-Site Evaluation in Nodular Liver Lesions: Cytology-Histopathology Correlation.
Article in Diagnostic cytopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionUSG/CT-guided FNACs are a safe, sensitive and specific method to diagnose various liver lesions. Nodular liver lesions have diverse etiologies. FNAC study of liver nodules can help in early diagnosis of various diseases and can also provide material for ancillary techniques if needed.
methodsForty-seven patients who were detected to have nodular liver lesions by USG/CT imaging were chosen and subjected to FNA with ROSE followed by trucut biopsy under USG/CT guidance. This study was done in age group of 30-85 years over a period of 18 months.
resultsOut of 47 cases in cytology, 17 cases (36.17%) were hepatocellular carcinomas, 8 cases (17.02%) were adenocarcinoma metastasis, 2 cases were each of granuloma (4.2%) and liver abscess (4.2%), one case was metastasis from squamous cell carcinoma (2.12%), and 6 cases were poorly differentiated carcinoma (12.7%); 7 cases (14.84%) were inconclusive cytologically, and 4 cases (8.5%) were cytologically negative. FNAC of liver lesions showed sensitivity of 95.10% and a specificity of 83%, positive predictive value was 97.50% and negative predictive value was 71.40%. Overall diagnostic accuracy was 93%. In our study, primary hepatocellular carcinoma is the most common malignancy (36%), followed by metastasis (17%). Females formed the majority of cases (52%) with peak incidence between 61 and 70 years.
conclusionUSG/CT-guided FNAC demonstrated high diagnostic accuracy especially when combined with ROSE and good cytology-histopathology concordance in the evaluation of nodular liver lesions.
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