ArticleFrontiers in oncology2026
Assessing the effectiveness of endoscopic submucosal dissection for hypopharyngeal lesions- a comprehensive evaluation.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Superficial hypopharyngeal carcinoma typically presents with no obvious clinical manifestations but poses significant management challenges due to its unique anatomical location and potential aggressiveness. Objective: To evaluate the clinical efficacy and safety of endoscopic submucosal dissection (ESD) in the treatment of superficial hypopharyngeal carcinoma. Methods: We retrospectively analyzed the clinical data of 11 patients with 13 superficial hypopharyngeal carcinomas who underwent ESD at the Gastrointestinal Endoscopy Center of Jiangsu Provincial Hospital of Traditional Chinese Medicine from November 2022 to November 2023. Results: All 11 patients were male, with 13 lesions located as follows: left pyriform fossa (53.8%), right pyriform fossa (23.1%), posterior hypopharyngeal wall (15.4%), and posterior cricoid region (7.7%). The average lesion diameter was 1.79 cm (range: 0.1-3.9 cm). The procedure took an average of 34 minutes (range: 10-90 minutes). Intraoperatively, subcutaneous cervicothoracic emphysema occurred in 1 patient (7.7%). Postoperatively, 5 patients (38.5%) reported postoperative pain, and 1 patient (7.7%) developed postoperative fever. During follow-up, choking symptoms were noted in 2 cases (18.2%), and hoarseness occurred in 4 cases (36.4%). The average length of hospitalization was 7.3 days (range: 5-10 days). Postoperative pathology revealed intraepithelial high-grade neoplasia in 46.2% of lesions, carcinoma Conclusion: ESD is a safe and effective treatment for superficial hypopharyngeal carcinoma and can be considered a viable option for the minimally invasive treatment of this condition.
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