ArticleFrontiers in oncology2026
Case Report: Negative initial endoscopy and 18F-FDG PET/CT may not exclude occult gastric cancer.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gastric cancer with ovarian metastasis (Krukenberg tumor) can mimic primary ovarian malignancy, creating diagnostic uncertainty. We report a female patient with peritoneal dissemination and bilateral adnexal masses, a presentation initially considered more suggestive of primary ovarian malignancy. However, initial EGD showed no definite gastric mass, and 18F-FDG PET/CT revealed no FDG-avid gastric primary lesion. Peritoneal biopsy revealed metastatic adenocarcinoma with a gastrointestinal-favoring immunophenotype, but repeat EGD was initially deferred due to clinical constraints. Empiric ovarian cancer-directed chemotherapy was started, followed by rapid progression. Repeat EGD later revealed an irregular ulcerative lesion at the gastric angle, and biopsy confirmed gastric adenocarcinoma with focal signet-ring cell components.
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