ArticleFrontiers in oncology2026
Diagnostic performance of contrast-enhanced ultrasound in distinguishing lymphoma from non-lymphoma lesions in salivary gland: a retrospective study.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Salivary gland lymphoma is a rare malignancy that is difficult to differentiate from other salivary gland lesions preoperatively. This study aimed to evaluate the diagnostic value of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in distinguishing salivary gland lymphoma from non-lymphoma lesions. Methods: This retrospective study included patients with salivary gland lesions who underwent ultrasound-guided biopsy or surgical resection at our institution between January 2019 and December 2024. US and CEUS features were compared between lymphoma and non-lymphoma lesions. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify independent predictors and evaluate diagnostic performance. Results: A total of 329 patients were included, comprising 36 salivary gland lymphomas and 293 non-lymphoma lesions. Significant differences were observed in lesion number, posterior echo, cystic components, color doppler flow imaging (CDFI), enhancement degree, enhancement pattern, early wash-in, and early wash-out (all Conclusion: These findings demonstrate that CEUS can serve an adjunct tool for the differential diagnosis of salivary gland lymphoma and non-lymphoma.
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