ArticleACS omega2026
Strategies for Enhancing Selectivity in Anticancer Metal Complexes.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
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Abstract
Anticancer metal complexes have always been a key aspect of chemotherapy. Platinum complexes such as cisplatin are commonly used. However, their lack of selectivity often leads to severe side effects. This review examines strategies that have been used to enhance the selectivity of metal complexes toward cancer cells and therefore, minimize toxicity toward healthy cells. These strategies have been categorized into passive targeting, active targeting, stimulus-responsive, structural modifications, subcellular targeting, delivery systems, external stimulus-controlled methods, and exploitation of tumor-specific biology. Each section discusses key scientific principles behind how the strategy works, examples, advantages, limitations, and recent advances or proposed methods for improvement. This Review aims to provide a consolidated resource for researchers aiming to design next-generation metal complexes with improved selectivity.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.