Evidence map›Paper›PMID 42294237›Full record

ArticleACS omega2026

Glyco-Conjugation of Thiosemicarbazone Copper(II) Complexes Enhances Selectivity toward Cancer Cells Overexpressing GLUT1.

Francesca Miglioli, Alessio Zavaroni, Cristina Marzano, Diego Montagner, Mauro Carcelli, Valentina Gandin, Dominga Rogolino

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesca MiglioliDepartment of Chemistry, Life Sciences, Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Alessio ZavaroniDepartment of Chemistry, Life Sciences, Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.ORCID https://orcid.org/0000-0002-9761-7247
Cristina MarzanoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, via F. Marzolo 5, 35131 Padova, Italy.ORCID https://orcid.org/0000-0003-0565-2596
Diego MontagnerDepartment of Chemistry, Maynooth University, Maynooth W23 F2H6, Ireland.ORCID https://orcid.org/0000-0002-1034-9623
Mauro CarcelliDepartment of Chemistry, Life Sciences, Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.ORCID https://orcid.org/0000-0001-5888-4556
Valentina GandinDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, via F. Marzolo 5, 35131 Padova, Italy.ORCID https://orcid.org/0000-0003-0442-0670
Dominga RogolinoDepartment of Chemistry, Life Sciences, Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.ORCID https://orcid.org/0000-0003-2295-5783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To overcome the limitations of conventional chemotherapy, specifically poor selectivity and systemic toxicity, this study explores a targeted approach leveraging the Warburg effect. We developed a series of novel copper-(II) glucose-conjugated thiosemicarbazones (C1-C4), rationally designed to enhance water solubility and achieve good selectivity toward cancer cells.

Identifiers

PMID42294237
PMCPMC13261448

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.