Evidence map›Paper›PMID 42294010›Full record

ArticleCritical care research and practice2026

Effects of a Glutamine and Arginine Combination on the Inflammatory Response in a Lipopolysaccharide-Induced Sepsis Model at Different Time Points of Supplementation.

Maulydia Maulydia, Nancy Margarita Rehatta, Subijanto Marto Soedarmo, Widjiati Widjiati

Abstract read
In one paragraph

Article in Critical care research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maulydia MaulydiaDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Universitas, Airlangga, Jl. Mayjen Prof. Dr. Moestopo 47, Surabaya, 60131, Indonesia.ORCID https://orcid.org/0000-0003-3248-4540
Nancy Margarita RehattaFaculty of Medicine, Petra Christian University, Jl. Siwalankerto 121-131, Surabaya, 60236, Indonesia, petra.ac.id.ORCID https://orcid.org/0000-0002-0696-8077
Subijanto Marto SoedarmoDepartment of Child, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr., Moestopo 47, Surabaya, 60131, Indonesia, unair.ac.id.ORCID https://orcid.org/0000-0002-8208-4417
Widjiati WidjiatiDepartment of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Jl. Dharmahusada Permai 1, Surabaya, 60115, Indonesia, unair.ac.id.ORCID https://orcid.org/0000-0002-8376-1176

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of the NF-κB signaling pathway in sepsis plays a crucial role in the expression of TNF-α, IL-8, and MMP-8, which can further exacerbate the condition. The management of sepsis requires complex strategies. Glutamine and arginine are amino acids that can modulate inflammatory processes and enhance immune function, and their levels are often deficient in sepsis. This study aimed to analyze the effects of glutamine and arginine combination (GAC) on TNF-α, NF-κB, IL-8, and MMP-8 expressions in sepsis. Seventy-two

Indexed as

arginineglutamineIL-8MMP-8sepsis

Identifiers

PMID42294010
PMCPMC13261681

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.