ArticleRegenerative therapy2026
Extracellular vesicles subpopulation derived of clonal mesenchymal stem cells protected retinal ganglion cells in mouse model with optic nerve crush.
Article in Regenerative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
Introduction: Recent studies have shown that Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have significant potential to protect retinal ganglion cells (RGCs) function. Here, EVs were obtained from various MSCs, including dental pulp MSCs, trabecular meshwork MSCs, and bone marrow-derived clonal MSCs (cMSCs). Methods: The different fractions of EVs were separated by high-speed (20K) and ultra-speed (110K) centrifugation. The functionality of EVs was then assessed in a mouse model of optic nerve crush (ONC). Results: The result showed that all EVs derived from various MSC sources could improve the optomotor response in ONC mice. Visual behavior and retrograde tracing of RGCs showed that both subpopulations of EVs derived from cMSCs were efficient and had a higher survival rate in Brn3a-positive RGCs. The ratio of Conclusions: These results suggest that the increased restoration of visual behavior after cMSC-EV-20K treatment may be related to the protection of the RGCs by multi-trophic factors in EVs. Because the production of the EV-20K fraction is more accessible with fewer facilities, it has more capacity to be translated into the clinics for the repair of damaged optic nerves.
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