ArticleFrontiers in psychology2026
Chronological age is differentially associated with cognitive performance according to climacteric stage: evidence from a Bayesian multivariate analysis in Chilean women.
Article in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Women traversing menopause experience neuropsychological changes affecting cognitive domains such as memory, attention, and processing speed. However, the relationship between chronological age and cognitive performance across different climacteric stages remains poorly understood, particularly in Latin American populations. The menopausal transition is increasingly recognized as a critical period for women's cognitive health, characterized by profound neuroendocrine changes that may influence trajectories of cognitive aging. Chronological age was associated with better cognitive performance in early menopause, whereas in advanced postmenopause it was associated with lower performance. This pattern may reflect stage-specific differences related to reproductive aging, particularly across different phases of the climacteric. Objectives: To examine whether chronological age differentially modulates cognitive performance according to climacteric stage in Chilean women from the Magallanes Region. Methods: Three hundred sixty women aged 50-81 years were recruited and classified by climacteric stage: early menopause (≤4 years since last menstrual period, Results: More advanced climacteric stage was associated with lower ACE-R and SDMT scores. Although the main effect of age at assessment showed high uncertainty, a significant age × climacteric stage interaction revealed that the age-cognition slope differed by stage. Specifically, in early menopause, older age was associated with better cognitive performance, whereas in advanced postmenopause, older age was associated with lower cognitive performance. Conclusion: The association between chronological age and cognitive performance differed according to climacteric stage in Chilean women. These findings challenge the traditional view of age as a uniformly negative correlate of cognition and may have implications for cognitive screening strategies during the menopausal transition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.