ReviewTranslational andrology and urology2026
Impact of bacteriospermia on sperm DNA fragmentation: a narrative review.
Review in Translational andrology and urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Background and Objective: Male infertility remains a significant global challenge, with bacteriospermia increasingly recognized as a contributor to impaired reproductive function. Emerging evidence suggests that bacterial infections may induce sperm DNA fragmentation. This narrative review aimed to evaluate the impact of bacteriospermia on sperm DNA fragmentation and to identify the underlying biochemical mechanisms and clinical implications for subfertile men. Methods: A comprehensive literature search was conducted across major databases, including PubMed/MEDLINE and Google Scholar, for studies published from 2008 to 2025. The search strategy employed keywords such as "DNA fragmentation", "bacteria", and "semen". Only peer-reviewed articles published in English were included to ensure data quality and relevance. Key Content and Findings: The prevalence of bacteriospermia varied by diagnostic method, ranging from 20.1-35.1% in polymerase chain reaction (PCR)-based assays and 15.28-34.88% in semen cultures. Regarding predominant strains, PCR tests most frequently identified Conclusions: Bacteriospermia might increase sperm DNA fragmentation significantly through oxidative stress, and well-designed prospective follow-up studies are warranted to further confirm these findings and establish definitive clinical protocols.
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