ArticleOman medical journal2025
Association of Serum Levels of Vitamins D and E with Markers of NLRP3-inflammasome Pathway in Multiple Sclerosis.
Article in Oman medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objectives: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. It is suggested that mechanisms of many diseases involve 'sterile inflammation' triggered by oxidative stress in the absence of infection. Inflammasomes regulate such inflammatory processes. Antioxidants can counter oxidative stress, but their exact relationship with inflammasome activity in MS is unclear. This study aimed to investigate the association between inflammasome markers and antioxidant vitamins D and E in Jordanian patients with MS. Methods: We enrolled 100 patients with MS and 100 healthy controls. Their blood samples were analyzed by enzyme-linked immunosorbent assay (ELISA) for levels of interleukin-18 (IL-18), IL-1 beta (IL-1β), nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3), and vitamins D and E. Results: Patients with MS had significantly higher serum levels of IL-18 ( Conclusions: Our findings suggest that inflammasome activation in MS is linked to decreased levels of antioxidant vitamins. Hence, inflammasome marker levels may serve as future potential biomarkers of disease activity and progression in MS.
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