ArticleObstetrics and gynecology international2026
Predictive Value of Neutrophils, Lymphocytes, Platelets, Neutrophil-Lymphocyte Ratio (NLR), and Platelets-Lymphocyte Ratio (PLR) in Preterm Labor: Single and Combined Indices.
Article in Obstetrics and gynecology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Predictive Value of Neutrophils, Lymphocytes, Platelets, Neutrophil-Lymphocyte Ratio (NLR), and Platelets-Lymphocyte Ratio (PLR) in Preterm Labor: Single and Combined Indices.Obstetrics and gynecology international · 2026Article
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10 authors.
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Abstract
Introduction: Maternal neutrophils (N), lymphocyte, platelets (PLTs), neutrophil-lymphocyte ratio (NLR), and platelets-lymphocyte ratio (PLR) have been used to predict preterm birth. We studied changes in these markers in preterm labor (PTL) and whether they can serve as single or combined predictive indicators. Material and Methods: Patients in premature labor participated in a retrospective case-control study. CBC, Hb, HCT, lymphocytes, N, PLTs, NLR, and PLR were measured and compared between total preterm cases (20 0/7-36 6/7 weeks) and normal pregnancies. Subgroups of early preterm labor (EPL) (20 0/7-33 6/7 weeks) and late preterm labor (LPL) (34 0/7-36 6/7 weeks) were also compared with gestational-age-matched controls. ROC curves were utilized to estimate the cutoff, specificity, sensitivity, and area under the curve (AUC) for every marker. According to cutoff levels of each marker, a score system was created (0-4). Combined Score Index and Systemic Immune-Inflammatory Index (SII) were calculated for total, early, and late preterm groups. Results: A total of 1000 patients with PTL were included. No significant difference was found in lymphocytes between groups. N, PLTs, NLR, and PLR were significantly higher in total PTL vs. controls. In EPL, N, PLTs, NLR, and PLR were significantly elevated ( Conclusion: Significant changes in N, PLTs, NLR, and PLR (both as individual and combined markers) are observed in PTL groups, but their predictive value for prematurity remains limited.
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