ArticleRadiology case reports2026
Ductal carcinoma in situ arising within a fibroadenoma in a 21-year-old woman: A case report.
Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Carcinoma arising within a fibroadenoma is exceptionally rare, particularly in young women, and may be underestimated in lesions classified as probably benign. We describe a 21-year-old woman with a 3 cm palpable breast mass categorized as Breast Imaging Reporting and Data System category 3, for which ultrasound-guided vacuum-assisted excision was performed due to lesion size and patient anxiety. Histopathology revealed low-grade cribriform ductal carcinoma in situ completely confined within a fibroadenoma, without invasion, consistent with malignant transformation of the epithelial component. A 113-gene germline panel identified no pathogenic variants, supporting a sporadic etiology of the disease. The patient subsequently underwent nipple-sparing mastectomy with sentinel lymph node biopsy and immediate reconstruction; final pathology confirmed pure ductal carcinoma in situ with clear margins and negative nodes. This case underscores the diagnostic limitations of imaging-based risk stratification in very young women with large category 3 fibroepithelial lesions and highlights vacuum-assisted excision and oncoplastic mastectomy as valuable options in individualized management.
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