Evidence map›Paper›PMID 42293400›Full record

ReviewMaterials today. Bio2026

Advances and challenges of metal-organic frameworks in controlled drug delivery.

Xingqi Zhu, Menghui Liao, Hao Wei, Yue Jiang, Hong Cheng, Xin Xu, Shan Xu, Yangnan Hu, Renjie Chai, Xiaoyun Qian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xingqi ZhuDepartment of Otolaryngology & Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, 210008, China.
Menghui LiaoSchool of Medical Engineering, Affiliated Zhuhai People's Hospital, Beijing Institute of Technology, Zhuhai, 519088, China.
Hao WeiDepartment of Otolaryngology & Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, 210008, China.
Yue JiangDepartment of Otolaryngology & Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, 210008, China.
Hong ChengDepartment of Otolaryngology Head and Neck Surgery, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Jiangsu Provincial Key Laboratory of Critical Care Medicine,School of Public Health, Advanced Institute for Life and Health, Southeast University, Nanjing, 210096, China.
Xin XuNorthern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 210993, China.
Shan XuDepartment of Otolaryngology, The First Hospital of China Medical University, Shenyang, 110001, China.
Yangnan HuSchool of Medical Engineering, Affiliated Zhuhai People's Hospital, Beijing Institute of Technology, Zhuhai, 519088, China.
Renjie ChaiSchool of Medical Engineering, Affiliated Zhuhai People's Hospital, Beijing Institute of Technology, Zhuhai, 519088, China.
Xiaoyun QianDepartment of Otolaryngology & Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, 210008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal-organic frameworks (MOFs) are a class of crystalline porous materials, which have become the main platform for drug delivery research because of their high specific surface area, adjustable pore size and high drug loading capacity. The selection of organic ligands, adjustment of metal nodes and post-synthetic modification enable precise control over drug loading, release kinetics and targeting specificity. These features overcome key limitations of traditional carriers, such as low loading capacity, easy inactivation and difficult biocompatibility. In addition, combining MOFs with stimulus-responsive polymers or photothermal agents has led to multifunctional systems that integrate therapeutic and diagnostic imaging, thereby enabling theranostic application. This review analyzes MOF surface engineering, stimulus response behavior, cytotoxicity and long-term biological interaction in detail. It also briefly describes the application of MOFs in various drug delivery modes, aiming to provide fundamental insights and guide the development of intelligent and adaptive drug delivery platforms for future biomedical applications.

Indexed as

BiocompatibilityDrug deliveryMetal-organic frameworksStimuli-responsive releaseTheranostics

Identifiers

PMID42293400
PMCPMC13264118

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.