Evidence map›Paper›PMID 42293321›Full record

ArticleBrain communications2026

Quantitative susceptibility mapping reveals widespread brain iron abnormalities in sporadic patients with early-stage amyotrophic lateral sclerosis.

Mingjie Ma, Bing Zhao, Ninglu Gao, Xiaohan Sun, Kai Shao, Pengfei Lin, Wei Li, Yuying Zhao, Dexin Yu, Chuanzhu Yan and 2 more

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Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

12 authors.

Mingjie MaSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Bing ZhaoDepartment of Neurology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266035, China.
Ninglu GaoDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Provincial Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Xiaohan SunDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Provincial Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.ORCID https://orcid.org/0000-0002-1926-583X
Kai ShaoDepartment of Clinical Laboratory, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266035, China.
Pengfei LinDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Provincial Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Wei LiDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Provincial Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Yuying ZhaoDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Provincial Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Dexin YuDepartment of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.ORCID https://orcid.org/0000-0002-3430-4817
Chuanzhu YanDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Provincial Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.ORCID https://orcid.org/0000-0002-2191-5184
Shuangwu LiuSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.ORCID https://orcid.org/0000-0002-9179-1543
Yan YunDepartment of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, using the novel quantitative susceptibility mapping technique, we aimed to systematically investigate brain iron alterations in a large group of sporadic early-stage amyotrophic lateral sclerosis patients and their correlation with clinical disability. In this study, amyotrophic lateral sclerosis patients at King's stage 1 were defined as early-stage amyotrophic lateral sclerosis patients, and 53 newly diagnosed early-stage amyotrophic lateral sclerosis patients and 50 healthy controls were included. Voxel-based whole-brain quantitative susceptibility mapping analysis was used to explore brain iron alterations. Voxel-based morphometry analysis was also performed. Longitudinal follow-up was performed in amyotrophic lateral sclerosis patients, and the follow-up progression rate was calculated. We found that, compared with healthy controls, early-stage amyotrophic lateral sclerosis patients presented significantly increased susceptibility values, mainly in the motor cortex, prefrontal cortex, hippocampus and cerebellar regions, while volumetric alterations were not detected. Moreover, motor and extra-motor cortex susceptibility values were significantly correlated with upper motor neuron scores and follow-up progression rate (

Indexed as

ALSmotor disabilityquantitative susceptibility mapping

Identifiers

PMID42293321
PMCPMC13256925

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