ArticleNeurobiology of stress2026
Differential associations between early life adversity subtypes and adolescent stress reactivity across neuroendocrine, autonomic, immune, and metabolic systems.
Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Early life adversity (ELA) is a heterogeneous construct that can include the consequences of poverty, maltreatment, or serious accidents. This study characterized associations between subtypes of ELA and the physiological responses of multiple systems to acute psychosocial stress. Studies to date have focused on HPA axis reactivity, often neglecting the stress-reactive SNS, HPG axis, metabolic, and innate immune systems. We hypothesized that emotional, physical, and non-intentional ELA would differentially affect stress reactivity in each of these systems. Nine salivary samples, collected serially across the administration of a Trier Social Stress Test for Children (TSST-C), were collected from 92 adolescents [mean age 13.9 (SD = 1.57)] and assayed for cortisol, testosterone, DHEA, uric acid, salivary ɑ-amylase, and interleukin-6 (IL-6). Emotional ELA was associated with a steeper cortisol response to the stressor [
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