ArticleJournal of advanced pharmaceutical technology & research
The effect of sucrose palmitate characteristics as a surfactant on the physical stability of red palm oil submicroemulsions.
Article in Journal of advanced pharmaceutical technology & research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Submicroemulsions are delivery systems that can enhance the solubility and stability of lipophilic compounds, such as red palm oil (RPO). This study aimed to evaluate the effects of sucrose palmitate (surfactant) on the characteristics and stability of RPO submicroemulsions. Four sucrose palmitate surfactants (SP1-SP4) with varying ester concentrations and hydrophilic-lipophilic balance (HLB) values were evaluated. Submicroemulsions were characterized based on globule size, polydispersity index (PDI), and zeta potential. Several methods were used to evaluate stability. These included a cycling test, three temperature conditions (5°C ± 3°C, 30°C ± 2°C, 40°C ± 2°C), Ostwald ripening rate, and a Lumifuge test. The results were analyzed using SPSS. Initial results showed that SP3 and SP4, with HLB values of around 17, produced the best globule characteristics, namely globule size below 180 nm, PDI below 0.15, and zeta potential <- 38 mV. However, the stability showed that SP1, with a high monoester concentration (≥90%), had the best stability and was not significantly different from SP4 (
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