SynthesisFrontiers in nutrition2026
Association of metabolic score for insulin resistance with gestational diabetes mellitus: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to systematically evaluate the association between the Metabolic Score for Insulin Resistance (METS-IR) and the risk of gestational diabetes mellitus (GDM). Methods: A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library up to March 2026. Two independent reviewers completed study screening, data extraction, and quality assessment. Cohort studies were evaluated with the Newcastle-Ottawa Scale, and cross-sectional studies were assessed with the Agency for Healthcare Research and Quality checklist. Meta-analyses were performed using Stata 16.0 and Review Manager 5.4.1. Heterogeneity was examined using the Cochrane Q-test and I Results: A total of 6 studies involving 93,995 pregnant women were included. The overall pooled odds ratio (OR) for GDM risk in the highest versus lowest METS-IR category was 2.53 (95% CI: 2.14-3.00, I Conclusion: Elevated METS-IR is significantly associated with increased GDM risk. As a noninvasive and cost-effective insulin resistance marker, METS-IR may serve as a reliable early predictor for GDM and support early screening in high-risk pregnant women. Further large-scale, multi-ethnic prospective studies are needed to validate these findings. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261355910, CRD420261355910.
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