ReviewFrontiers in nutrition2026
Administration of ketogenic intervention as a potential treatment during post-traumatic brain injury recovery: a scoping review.
Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
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Abstract
Background: Traumatic brain injury (TBI) affects 69 million individuals annually and represents a major global health burden. Ketogenic interventions have emerged as a potential therapy to address deficits following TBI. This scoping review updates previous work to synthesize evidence on ketogenic therapies for TBI, examining mechanistic insights, clinical feasibility, and barriers. Methods: A systematic search was conducted following the methodological framework of Arksey and O'Malley (2005) and JBI guidance. Findings are reported in accordance with PRISMA 2020 guidelines complemented by the PRISMA Extension for Scoping Reviews (PRISMA-ScR). Studies were included if they used TBI models in human or animal subjects; investigated ketogenic interventions; reported quantitative clinical, functional, or metabolic outcomes; and enrolled more than five participants in clinical trials. Studies were excluded if they were conducted Results: Out of 421 studies screened, 32 studies met the inclusion criteria. 25 animal studies and 7 human studies were analyzed. 68.0% of animal studies used exclusively male specimens. The total pooled male-to-female ratio across human studies was 53:24, reflecting an approximately twofold predominance of male participants. Studies were evaluated using clusters of the most-assessed frameworks. Animal investigations evaluated metabolic pathways in 23 out of 25 (92.0%) studies, neuroprotective effects in 15 out of 25 (60.0%) studies, and behavioral assays in 13 out of 25 (52.0%) studies. Human studies assessed feasibility in 7 out of 7 (100%) studies, safety in 5 out of 7 (83.33%) studies, and efficacy in 4 out of 7 (66.67%) studies. Clinical trials consistently demonstrated feasibility in monitored settings. Conclusion: Ketogenic interventions improve metabolic dysfunction in preclinical models with variable neuroprotective and functional effects. Clinical evidence demonstrates feasibility but lacks adequately powered efficacy trials. Larger controlled trials with standardized endpoints with balanced age and sex representation are needed to determine efficacy.
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