SynthesisFrontiers in nutrition2026
The role of nutritional vitamin D on microinflammation and nutritional status in maintenance hemodialysis patients: a meta-analysis of randomized controlled trials.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Microinflammation is widespread in Maintenance hemodialysis (MHD) patients. The continuous interaction of microinflammation and malnutrition is an independent risk factor for the clinical prognosis of MHD patients. Nutritional vitamin D deficiency is closely related to chronic kidney disease inflammation, but whether correcting this deficiency can improve microinflammation in the MHD population remains unclear. Methods: Studies published up to March 1, 2025 were included. Risk of bias was assessed using the Cochrane tool. RevMan 5.4 and Stata 17 were used for analyses, with heterogeneity assessed and random-effects models applied. Key outcomes included CRP, serum albumin, TNF-α, IL-1β, immunoreactive Parathyroid Hormone (iPTH), adverse events, hypercalcemia, and hyperphosphatemia. Results: A total of 617 patients in eight randomized controlled trials were included. The experimental group interventions were nutritional vitamin D, while those of the control group were placebo. The meta-analysis showed that the decrease in CRP in the nutritional vitamin D intervention group was significantly higher than that in the control group [MD -3.15, 95% confidence interval (CI; -4.46, -1.84), Conclusion: Nutritional vitamin D supplementation may improve microinflammation and nutritional status in MHD patients, with potential benefits for bone metabolism and no apparent increase in the risk of hypercalcemia or hyperphosphatemia.
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