ArticlePatient preference and adherence2026
Trajectories and Influencing Factors of Depression in Patients with H-Type Hypertension-Related Ischemic Stroke: A Single-Center Longitudinal Study.
Article in Patient preference and adherence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to identify depression trajectory patterns in patients with H-type hypertension-related ischemic stroke and explore predictors using the COM-B framework. Methods: A prospective longitudinal study enrolled 588 patients from a Chinese tertiary hospital (September 2023-December 2024). Data were collected at six time points (admission and 1, 3, 6, 9, 12 months post-discharge). Growth mixture modeling identified trajectory classes, and multivariate logistic regression determined predictive factors. Results: Four depression trajectory classes were identified: (1) Rapid Recovery group (n=155, 26.4%): swift symptom resolution; (2) Moderate Improvement group (n=70, 11.9%): moderate symptom improvement; (3) Persistent Low-Symptom group (n=102, 17.3%): optimal reference category; (4) Symptom-Aggravation group (n=261, 44.4%): exacerbation over time. Protective factors included positive health behaviors (strongest across all comparisons), first-time stroke onset, urban residence, and employed status (all p < 0.05). Risk factors included higher health knowledge levels, elevated homocysteine, unemployed/retired status, and higher social support. Notably, elevated homocysteine and higher social support were associated with worsening depression, especially in the Symptom-Aggravation group (p < 0.05). Conclusion: Four distinct depression trajectories were identified in H-type hypertension-related ischemic stroke patients, with specific predictors. These findings inform targeted interventions to improve depression outcomes.
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