Evidence map›Paper›PMID 42293153›Full record

ArticleFrontiers in aging neuroscience2026

Relationship between high-sensitivity C-reactive protein/lymphocyte ratio and post-thrombolysis short-term outcome in acute ischemic stroke patients.

Ruixiu Zhu, Gang Chen, Yaya Fei, Jiajie Lu, Chenxue Xu, Yuying Xia, Zhiyu Zhang, Xindi Jiang, Shuaiyu Chen, Xiaohao Zhang and 5 more

Abstract read
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In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

15 authors.

Ruixiu Zhu *Department of Geriatrics, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University, Nantong, Jiangsu, China.
Gang Chen *Department of Neurology, Haimen Hospital Affiliated to Nantong University, Nantong, Jiangsu, China.
Yaya FeiDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Jiajie LuDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Chenxue XuDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Yuying XiaDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Zhiyu ZhangDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Xindi JiangDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Shuaiyu ChenDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Xiaohao ZhangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Yi XieDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Jianhua SongDepartment of Neurology, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University, Nantong, Jiangsu, China.
Yuechun WangDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.
Yachi GongDepartment of Geriatrics, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University, Nantong, Jiangsu, China.
Pengyu GongDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: High-sensitivity C-reactive protein / lymphocyte ratio (hsCLR) was emerged as a promising novel biomarker for various diseases. However, the relationship between hsCLR and short-term outcome in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) remained unclear. Methods: This multicenter study included 904 AIS patients undergoing IVT. Multivariate logistic regression and restricted cubic spline (RCS) analysis were used to explore the association between hsCLR levels and unfavorable short-term outcomes after thrombolysis. Receiver operating characteristic (ROC) analysis was performed to evaluate the prognostic performance of hsCLR. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) analyses were further conducted to assess the incremental prognostic value of adding hsCLR to conventional risk models. Results: We found that patients with higher levels of lnhsCLR were more likely to experience short-term unfavorable outcome ( Conclusion: Elevated baseline hsCLR is associated with unfavorable short-term outcomes and may serve as a promising prognostic biomarker in AIS patients undergoing intravenous thrombolysis.

Indexed as

acute ischemic strokebiomarkerhigh-sensitivity C-reactive protein/lymphocyte ratiointravenous thrombolysisshort-term functional outcome

Identifiers

PMID42293153
PMCPMC13260141

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