Evidence map›Paper›PMID 42293148›Full record

ArticleFrontiers in aging neuroscience2026

Lateralization of interictal epileptiform discharges differently impacts cognitive performance and behavior in late-onset epilepsy of unknown aetiology.

Giusy Bergamo, Mariana Fernandes, Gianluca Albanesi, Matteo Antonucci, Ilaria Barbaro, Beatrice Bertini, Flavia Cirillo, Valentina Corsi, Silvia Maio, Greta Testone and 3 more

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Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Giusy BergamoDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Mariana FernandesDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Gianluca AlbanesiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Matteo AntonucciDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Ilaria BarbaroNeurology Unit, University Hospital of Tor Vergata, Rome, Italy.
Beatrice BertiniNeurology Unit, University Hospital of Tor Vergata, Rome, Italy.
Flavia CirilloNeurology Unit, University Hospital of Tor Vergata, Rome, Italy.
Valentina CorsiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Silvia MaioNeurology Unit, University Hospital of Tor Vergata, Rome, Italy.
Greta TestoneDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Nicola B MercuriDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Diego CentonzeDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Claudio LiguoriDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Late-onset epilepsy of unknown aetiology (LOEU) is increasingly recognized as a multifactorial condition potentially linked to preclinical neurodegeneration. Despite its clinical relevance, the impact of lateralized interictal epileptiform discharges (IEDs) on cognitive and behavioral phenotypes remains poorly understood. Methods: We conducted an observational cross-sectional study of 62 LOEU patients (66.1 ± 7.3 years). All participants underwent neurological examination, electroencephalography, and a neuropsychological battery. Subjective sleep quality (Pittsburgh Sleep Quality Index), daytime sleepiness (Epworth Sleepiness Scale), depressive symptoms (Beck Depression Inventory-II), and quality of life (Quality of Life in Epilepsy Inventory-31) were also assessed. Patients were stratified based on IED lateralization (Left vs. Right). Results: IEDs were left-lateralized in 61.3% ( Conclusion: While right-sided IEDs were associated with lower RAVLT-D performance, this represents a nominally significant finding in the context of multiple domains tested without correction for multiple comparisons. These results may suggest a distributed pattern of cognitive vulnerability, possibly reflecting network dysfunction or inefficient interhemispheric integration. Findings should be interpreted with caution and considered exploratory. Given that RAVLT-D is a marker of hippocampal dysfunction and early neurodegeneration, these results support longitudinal monitoring to identify LOEU patients at higher risk of dementia, regardless of focal lateralization.

Indexed as

delayed verbal memoryIEDslate-onset epilepsyMCIneurodegeneration

Identifiers

PMID42293148
PMCPMC13253965

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