ArticleNeuropsychiatric disease and treatment2026
Alcohol Cues Elicit Differences in Brain Activation Patterns of Abstinent Men and Women with Alcohol Use Disorders.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cognitive, emotional, and behavioral abnormalities have been associated with alcohol use disorders (AUD). Because of their reward salience, photographs of alcoholic beverages can influence brain activation in individuals with AUD. Methods: We employed fMRI to measure gender differences in brain activation elicited by alcohol cues in 84 men and women with and without a history of alcohol use disorders (ALC and NC, respectively). Brain activity was measured during performance on a delayed matching-to-sample (DMTS) working memory task; emotional faces served as the sample and match cues. During the delay period, intervening distractors were either reward-salient cues (alcoholic beverages) or neutral cues (nonalcoholic beverages or scrambled pictures). Results: Region of interest analyses showed that the ALC group had significantly higher levels of activation throughout reward-related circuitry during alcohol distractor interference than during scrambled picture interference. Significant Group-by-Gender interactions were also observed: Compared to NC men (NCm), ALC men (ALCm) evidenced lower activation contrast between reward-salient cues and neutral cues in Discussion: The findings suggest that abstinent ALCm and ALCw differ in processing reward-salient cues, which can impact treatment and recovery.
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