Evidence map›Paper›PMID 42293045›Full record

ArticleOrthopaedic journal of sports medicine2026

Magnetic Resonance Imaging Assessment of Bridge-Enhanced ACL Restoration: An Imaging Atlas of Morphological Features and Healing Trajectories.

James A Pruneski, Shankar G Kaushal, Kirsten Ecklund, Dennis E Kramer, Yi-Meng Yen, Lyle J Micheli, Braden C Fleming, Martha M Murray, Ata M Kiapour

Registry-linked trialAbstract read
In one paragraph

Article in Orthopaedic journal of sports medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02664545 (A Prospective, Randomized, Controlled, Clinical Trial Evaluating the Non-Inferiority of Bridge-Enhanced Anterior Cruciate Ligament Repair), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02664545 naactive not recruitingnot on this map

A Prospective, Randomized, Controlled, Clinical Trial Evaluating the Non-Inferiority of Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) to Anterior Cruciate Ligament Reconstruction With an Autologous Tendon Graft (ACLR)

TypeinterventionalSponsorMiach OrthopaedicsRan2016 to 2028Enrolled100ConditionsAnterior Cruciate Ligament TearArmsBEAR Scaffold, Tendon Graft
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James A PruneskiDepartment of Orthopedics and Sports Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-8645-9386
Shankar G KaushalDepartment of Orthopedics and Sports Medicine, Boston, Massachusetts, USA.
Kirsten EcklundDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Dennis E KramerDepartment of Orthopedics and Sports Medicine, Boston, Massachusetts, USA.
Yi-Meng YenDepartment of Orthopedics and Sports Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-1306-4201
Lyle J MicheliDepartment of Orthopedics and Sports Medicine, Boston, Massachusetts, USA.
Braden C FlemingDepartment of Orthopedics, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0002-7841-425X
Martha M MurrayDepartment of Orthopedics and Sports Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-5086-9511
Ata M KiapourDepartment of Orthopedics and Sports Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7742-5769

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The use of bridge-enhanced anterior cruciate ligament (ACL) restoration (BEAR) procedures is on the rise. Yet, there is a paucity of literature describing the radiographic appearance of the ACL after this procedure. Purpose: To present the quantitative and qualitative postoperative changes in healing ACLs within the first 24 months after an ACL restoration procedure. Study Design: Case series; Level of evidence, 4. Methods: A total of 64 patients (64 knees, 19.4 ± 5 years, 57% women) underwent magnetic resonance imaging (MRI) of the knee 6, 12, and 24 months after ACL restoration surgery with an extracellular matrix scaffold as part of a randomized-controlled trial. The ACL sagittal elevation angle and tunnel positions, along with ACL volume, mean cross-sectional area (CSA), length, and normalized signal intensity (SI), were quantified from MRI. Patients were divided into quartiles based on SI at 24 months after surgery for inclusion in the qualitative analysis with an adapted framework for assessing tissue quality. Additional cases were selected for qualitative analysis based on clinical representations. Linear mixed modeling with Tukey post hoc corrections was used to analyze quantitative ACL healing parameters. Results: Tunnel positions were anatomic in 26.6% of femurs and 68.8% of tibias. The healing ACL sagittal elevation angle remained stable (<1° change between postoperative time points; Conclusion: The present study demonstrates that throughout 2 years of serial imaging after an ACL restoration procedure, the healing ACL becomes smaller cross-sectionally and more organized (lower normalized SI). Despite changes in the ACL size and ACL SI, the sagittal orientation remains unchanged and comparable with the contralateral native ACL. In the qualitative analysis, 7 distinct healing trajectories were identified. These data are important for interpreting postoperative imaging after the BEAR procedure, and for identifying that several healing trajectories exist after a restoration procedure. Further studies are warranted to identify patient-specific factors that may influence these trajectories. Registration: NCT02664545 (ClinicalTrials.gov identifier).

Indexed as

anterior cruciate ligamentbridge-enhanced anterior cruciate ligamenthealingmagnetic resonance imagingquantitative magnetic resonance imagingrepairrestoration

Identifiers

PMID42293045
PMCPMC13254427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.