ArticleDepression and anxiety2026
Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non-Remission in Patients With Major Depressive Disorder.
Article in Depression and anxiety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non-Remission in Patients With Major Depressive Disorder.Depression and anxiety · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aimed to investigate the neural basis of individual differences in antidepressant efficacy using an 8-week longitudinal multitime point resting-state functional magnetic resonance imaging (fMRI) design. Methods: Forty-eight patients with major depressive disorder (MDD) completed two or three scans, and 44 healthy controls (HCs) underwent a baseline scan. Patients were categorized into remission (MDDr) and nonremission (MDDnr) groups based on treatment outcomes. Group differences in resting-state functional connectivity (rsFC) of the amygdala subregions at baseline were examined among MDDr, MDDnr, and HCs. Longitudinal changes in the identified rsFC were compared between the MDDr and MDDnr groups. Correlation analyses were conducted to explore the relationship between baseline rsFC or its longitudinal changes and depressive symptom severity or improvement. Results: At baseline, rsFC between the right basolateral (BL) amygdala and the right supplementary motor area (SMA) was lower in the MDDr group but higher in the MDDnr group compared with HCs, although this effect did not survive multiple comparisons correction across amygdala subregions. The trajectory of this rsFC differed between the two patient groups during treatment, with normalization observed at 2 and 8 weeks posttreatment. Correlation analyses indicated that baseline rsFC was associated with treatment response and that longitudinal changes in rsFC were aligned with symptom improvement, although some associations did not survive multiple comparisons correction. Conclusions: Our findings provide novel and valuable insights into the neural mechanisms underlying antidepressant response and highlight the role of amygdala subregional connectivity in explaining interindividual variability in treatment efficacy. Trial Registration: ClinicalTrials.gov identifier: ChiCTR2400093823.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.