Evidence map›Paper›PMID 42292911›Full record

ArticlebioRxiv : the preprint server for biology2026

Functional characterization and classification of mechanosensitive bladder afferents.

Guadalupe Manrique-Maldonado, Xuejiao Sun, Stephanie L Daugherty, Jonathan M Beckel, Marcelo D Carattino

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guadalupe Manrique-MaldonadoRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Xuejiao SunRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Stephanie L DaughertyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jonathan M BeckelDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Marcelo D CarattinoRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Funding

Resource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas R Kleyman · 2023 to 2026
$4.8M
Role of fibroblasts in bladder mucosal functionR01DK138907 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerard L Apodaca, Marcelo Daniel Carattino · 2025 to 2026
$1.4M
Role of acid-sensing ion channels in bladder sensory signalingR01DK134431 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARATTINO, MARCELO DANIEL · 2023 to 2025
$941k
Leica Stellaris Confocal for Kidney Imaging CoreS10OD028596 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2021 to 2021
$596k
NIDDK NIH HHS R01 DK134431NIDDK NIH HHS R01 DK138907NIDDK NIH HHS U54 DK137329NIH HHS S10 OD028596
6 · The paper itself

Abstract

Normal urinary bladder function relies on afferent fibers that detect and integrate mechanical and chemical cues related to bladder distension. Though, the molecular identity and function of the various sensory neuron types involved in bladder function have yet to be fully elucidated. Here, we introduce a novel framework for the functional classification of mechanosensitive bladder afferents based on their differential responses to physiological (15 μl/min) and noxious filling (30 s at intravesical pressures of 10, 20, 30, 40, 50, and 60 cmH

Indexed as

afferent activityPIEZO channelssensory neuronsurinary bladderYoda1

Identifiers

PMID42292911
PMCPMC13254814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.