Evidence map›Paper›PMID 42292910›Full record

ArticlebioRxiv : the preprint server for biology2026

Label-free 3D virtual histology of human formalin-fixed paraffin-embedded (FFPE) prostate needle biopsies with propagation-based phase-contrast micro-CT (PBCT).

Andrew Sugarman, Daniel Vanselow, Guoli Chen, Elizabeth Clark, Dilworth Parkinson, Patrick La Riviere, Justin Silverman, Joshua Warrick, Keith C Cheng

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrew SugarmanCenter for Computational Phenomics, Pennsylvania State University.ORCID 0000-0003-3348-2977
Daniel VanselowCenter for Computational Phenomics, Pennsylvania State University.ORCID 0000-0002-9221-8634
Guoli ChenDepartment of Pathology, Penn State College of Medicine, Hershey, PA, USA.
Elizabeth ClarkAdvanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Dilworth ParkinsonAdvanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Patrick La RiviereDepartment of Radiology, The University of Chicago, Chicago, IL, USA.ORCID 0000-0003-3415-9864
Justin SilvermanInstitute for Computational and Data Sciences, Pennsylvania State University, State College, PA, USA.ORCID 0000-0002-3063-2098
Joshua WarrickDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6149-1331
Keith C ChengCenter for Computational Phenomics, Pennsylvania State University.ORCID 0000-0002-5350-5825

Funding

Groundwork for a Synchrotron MicroCT Imaging Resource for Biology (SMIRB)R24OD018559 · OD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHENG, KEITH CHI · 2015 to 2022
$6.4M
Building a Wide-field, High-resolution Histotomography Resource for BiologyR24OD035407 · OD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Keith Chi Cheng · 2024 to 2026
$2.8M
NIH HHS R24 OD018559NIH HHS R24 OD035407
6 · The paper itself

Abstract

For over a century, the goal of estimating clinical outcome from tumor biopsies has been based on histomorphology of 2D tissue slices that represent a small fraction of collected samples. Its power derives from histology's 1)

Indexed as

3D virtual histologyGleason scorehistologyhistopathologymicro-CTphase contrastprostate cancer

Identifiers

PMID42292910
PMCPMC13261793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.