ArticleInternational journal of women's health2026
Association Between Baseline Mammographic Breast Density and the Incidence of Natural Menopause in Korean Women: A Nationwide Population-Based Study Using National Health Screening Data.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: High mammographic breast density (MBD) reflects cumulative exposure to sex hormones. While it is well established that breast density declines during the menopausal transition, the association between baseline MBD and the subsequent timing of natural menopause remains underexplored. We investigated the relationship between baseline MBD and incident natural menopause in Korean women. Methods: We conducted a retrospective cohort study using the Korean National Health Insurance Service database. A total of 428,998 premenopausal women aged 40-55 years who underwent breast cancer screening in 2009 were included. Baseline MBD was classified using the BI-RADS system. Incident natural menopause was defined by consistent self-reports across at least two subsequent screenings (2011-2013). Multivariate logistic regression models were used to estimate odds ratios (ORs) for incident menopause, adjusting for confounders including age, BMI, and reproductive history. Results: A total of 73,599 women (17.16%) experienced natural menopause. Higher MBD was associated with progressively lower odds of incident menopause. Women with extremely dense breasts exhibited the lowest likelihood of reaching menopause (adjusted OR 0.8, 95% CI 0.77-0.83), indicating a delayed menopausal transition. Stratified analyses revealed that the inverse association was more pronounced in women age <50 years and those with late menarche (≥13 years). Conclusion: High premenopausal MBD was independently and inversely associated with the incidence of natural menopause, suggesting a potential link between dense fibroglandular tissue and variations in reproductive aging. Clinically, baseline MBD could potentially serve as a readily available indicator to evaluate reproductive aging patterns, aiding in more personalized health counseling regarding reproductive health and surveillance strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.