SynthesisFrontiers in pharmacology2026
Multidimensional toxicity of snake venom causes multi-organ damage and treatment challenges: a narrative review.
Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Snakebite envenomation has become a global public health challenge due to the widespread distribution of venomous snakes. Snake venom, a complex mixture containing various bioactive components, exhibits distinct characteristics across different families. The core toxic components of snake venom are mainly Three-Finger Toxins (3FTxs), phospholipase A2(PLA2), and proteases, which together form the material basis of the venom's multidimensional toxicity. Through synergistic effects, they activate common pathological pathways, enabling targeted disruption of multiple human organs., leading to acute injury and even multi-organ failure. Beyond the acute effects, some survivors may experience long-term sequelae such as chronic kidney disease or permanent musculoskeletal damage. Existing research suggests that snake venom may have modulatory effects on the immune system, however, the relevant evidence primarily comes from
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