ArticleJournal of biomedical physics & engineering2026
Article in Journal of biomedical physics & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. Despite advancements in radiotherapy, its effectiveness is limited due to challenges in delivering high doses without harming healthy tissues. Objective: The current study aimed to determine whether Urtica dioica extract could enhance the cytotoxic effects of radiation on U87MG glioma cells and explore the underlying mechanisms. Material and Methods: This Results: Urtica dioica extract exhibited a concentration and time-dependent cytotoxic effect on U87MG cells. Notably, combining the extract with radiotherapy resulted in a significantly greater reduction in cell viability compared to either treatment alone. Cell cycle analysis revealed that the combination treatment induced G2/M phase arrest more effectively than either treatment alone. Additionally, Urtica dioica extract enhanced the pro-apoptotic effects of radiation, indicated by a significant increase in the late apoptotic cell population. Conclusion: This study demonstrates the radiosensitizing properties of Urtica dioica extract in U87MG glioma cells. The extract promotes cell cycle arrest and apoptosis, potentially leading to improved radiotherapy efficacy. These findings suggest Urtica dioica as a promising complementary therapy for GBM treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.