ArticleFrontiers in chemistry2026
Physicochemical behaviour of acetaminophen-Dimethyl Sulphoxide mixtures studied via dielectric spectroscopy.
Article in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: This research examines the dielectric and electrical properties of binary mixtures of acetaminophen (APAP) with Dimethyl Sulfoxide (DMSO) as a means to comprehend their molecular interactions, polarization behaviour, and charge transport mechanisms that are characteristic of pharmaceutical systems. Methods: The binary mixtures were examined with the help of a broadband dielectric spectrometer, specifically using the Novocontrol Technologies Alpha-A Analyzer, within a frequency range from 10 Hz to 10 MHz at a temperature of 25 °C and the application of a bias voltage of 0.1 V. The variations of the real and imaginary parts of complex permittivity, complex conductivity, and electric modulus with frequency for different APAP concentrations in DMSO were thoroughly studied. Besides, impedance spectroscopy and equivalent circuit modelling were also used to study the interfacial polarization and conduction processes. Results: Strong electrode polarization effects were found in the dielectric spectra at the low-frequency range, along with evident conduction relaxation behaviour. The concentration-related changes in dielectric parameters revealed strong intermolecular interactions and alterations in charge transport dynamics within the binary mixtures. Impedance analysis and equivalent circuit modelling also supported the existence of interfacial polarization phenomena and generated details about the conductive pathways functioning in the system. Discussion: This paper unveils the dielectric response and electrical interaction behaviour of the APAP-DMSO mixtures in detail. The results may help future studies seeking to improve pharmaceutical preparations and deepen the understanding of solvent-facilitated molecular interactions in drug delivery systems.
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