ArticleThe journal of allergy and clinical immunology. Global2026
Extended multisystem manifestations of hereditary α-tryptasemia in an allergy center cohort.
Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hereditary α-tryptasemia (HαT) is a common autosomal-dominant trait caused by additional copies of the gene Objective: We sought to delineate the spectrum and burden of extended manifestations observed in patients with and without HαT presenting to an allergy department. Methods: A total of 332 allergy patients with BST ≥ 8 μg/L were prospectively enrolled. Blood was tested for HαT and Results: HαT-positive patients reported a significantly higher symptom burden than HαT-negative patients (9.3 vs 6.5; Conclusion: HαT may have a broader clinical impact beyond classic allergy-immunology connections and may be associated with extended clinical phenotypes. This suggests an integrative approach to medical practice in allergy patients.
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