ArticleTranslational pediatrics2026
Detection of elevated levels of taurine and creatine in the brain of hypoxic-ischemic newborn rat using a magnetic resonance spin echo full intensity acquired localization sequence.
Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is a major perinatal neurological disorder with limited objective early diagnostic markers, while conventional point resolved selective spectroscopy (PRESS)-based Methods: Six male newborn rats were used for making HIE model induced by unilateral common carotid artery ligation followed by hypoxia. Hippocampal damage in the HIE model rat was confirmed by hematoxylin and eosin (HE) staining. T2-weighted anatomical images and Results: SPECIAL MR spectra are feasible in newborn HIE rat brain corresponding to the ligation side with higher spectral resolution compared with PRESS spectra. Elevated levels of Tau and Cr + PCr were found in the right hippocampus by SPECIAL spectra (P<0.05), and increased levels of Cr + PCr, Lac + MM14 + Liq13, and decreased NAA were observed by PRESS spectra (P<0.05). More correlations between metabolites were found from SPECIAL spectra than PRESS spectra, including Tau and Cr + PCr (r=0.7, P<0.01), Glu + Gln and Cr + PCr (r=0.75, P<0.01), GPC + PCh and Cr + PCr (r=0.63, P<0.01), and Lac + MM14 + Liq13 and Cr + PCr (r=0.54, P=0.03). Conclusions: The use of SPECIAL sequences could provide more information on metabolic changes in the HIE rat brain, and Tau and Cr + PCr may be considered as reliable metabolic markers for earlier and accurate assessments of the damage of hypoxic-ischemic.
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