Evidence map›Paper›PMID 42292518›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Liposomes as delivery vectors for nucleic acid mimics into

João P Santos, Eva Pinho, Rita S Santos, Joana A Loureiro, Maria C Pereira, Rui M Ferreira, Céu Figueiredo, Emílio Gomes, Joana Castro, Daniela Araújo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

João P SantosLEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.
Eva PinhoINIAV - National Institute for Agrarian and Veterinary Research, Vairão, Portugal.
Rita S SantosLEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.
Joana A LoureiroLEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.
Maria C PereiraLEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.
Rui M Ferreirai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Céu Figueiredoi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Emílio GomesLEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.
Joana CastroINIAV - National Institute for Agrarian and Veterinary Research, Vairão, Portugal.
Daniela AraújoINIAV - National Institute for Agrarian and Veterinary Research, Vairão, Portugal.
Nuno M GuimarãesLEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.
Nuno F AzevedoLEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing threat of antimicrobial resistance (AMR) requires the development of novel therapeutic solutions and Nucleic Acid Mimics (NAMs) arepresent a promising alternative. NAMs can hybridize with intracellular bacterial mRNA, working as antisense oligonucleotides (ASOs), being therefore potentially applied as targeted therapeutics (ASObiotics). Because NAMs do not naturally penetrate the bacterial envelope, effective delivery vectors are required. Liposomes represent a promising strategy to overcome this barrier, but their interaction with bacterial envelopes remains poorly understood. Here, we evaluated multiple liposomal formulations as delivery vectors for Cy3-labelled LNA/2'-O-methyl NAMs, targeting the essential

Indexed as

antimicrobial resistance (AMR)ASOsEscherichia coliliposomesNAMspolyclonal antibodies

Identifiers

PMID42292518
PMCPMC13253889

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.