Evidence map›Paper›PMID 42292484›Full record

ArticleFrontiers in immunology2026

Good's syndrome and infections in a large retrospective cohort of thymoma.

Wenji Jia, Lei Jin, Xiao Huan, Chong Yan, Jianying Xi, Liewen Pang, Chongbo Zhao, Jie Song, Xianglin Chu, Sushan Luo

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Wenji Jia *Department of Neurology, No.2 Affiliated Hospital, Kunming Medical University, Kunming, China.
Lei Jin *Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
Xiao HuanHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
Chong YanHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
Jianying XiHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
Liewen PangDepartment of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Chongbo ZhaoHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
Jie SongHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.
Xianglin ChuDepartment of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Sushan LuoHuashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Good's syndrome (GS) is an immunodeficiency associated with thymoma characterized by hypogammaglobulinemia. The co-existence of recurrent infections may be associated with quality of life and overall survival. Despite its relevance, the impact of GS on patients with thymoma has rarely been studied in large cohorts. Methods: This is a retrospective cohort study of patients with pathologically confirmed thymoma recruited between May 2010 and November 2024. Data on peripheral immune profile, infections, and paraneoplastic syndrome (PNS) were collected and analyzed. Results: Of 1001 patients with thymoma, we ultimately included 158 patients who underwent peripheral immune profiling. The prevalence of GS was 45.6% (72/158), and the infections were reported in 43.69% (69/158). Infection rates were higher in the GS group than in non-GS group (50% versus 32.72%, Conclusion: GS and infections are prevalent in patients with thymoma. Infections and multiple PNS were associated with poorer survival outcomes. These findings highlight the importance of early detection and intervention for improving prognosis and long-term survival in patients with thymoma.

Indexed as

AgammaglobulinemiaImmunologic Deficiency SyndromesInfectionsThymomaThymus NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedParaneoplastic SyndromesPrevalenceRetrospective StudiesGood’s syndrome (GS)immunodeficiencyimmunologyinfectionoverall survivalthymoma auto-immunity

Identifiers

PMID42292484
PMCPMC13253672

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.