Case Report: successful non-surgical management of massive isolated tricuspid Libman-Sacks endocarditis in a pregnant patient with SLE and secondary APS.

Jiaoniu Duan, Lin Han, Wenli Zhao, Gailian Zhang

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Jiaoniu DuanThe Rheumatology and Immunology Department of Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.

Lin HanThe Rheumatology and Immunology Department of Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.

Wenli ZhaoThe Ultrasound Department of Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.

Gailian ZhangThe Rheumatology and Immunology Department of Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Isolated tricuspid valve Libman-Sacks endocarditis (LSE) is extremely rare, and its occurrence during pregnancy with severe thrombocytopenia poses major diagnostic and therapeutic challenges. Case summary: A 21-year-old pregnant woman at 13 weeks of gestation with systemic lupus erythematosus (SLE) and secondary antiphospholipid syndrome (APS) presented with severe thrombocytopenia (platelet count 21 × 10 Conclusion: This case demonstrates that intensive immunomodulatory therapy combined with timely anticoagulation after partial platelet recovery can achieve vegetation regression and avoid cardiac surgery in pregnant patients with SLE/APS and massive isolated tricuspid LSE. To our knowledge, this is the first reported case of non-surgical management of this life-threatening condition.

Indexed as

Antiphospholipid SyndromeEndocarditisLupus Erythematosus, SystemicTricuspid ValveAnticoagulantsEchocardiographyFemaleHumansImmunoglobulins, IntravenousPregnancyTreatment OutcomeYoung AdultAnticoagulantsImmunoglobulins, Intravenousantiphospholipid syndromeLibman-Sacks endocarditispregnancysystemic lupus erythematosusthrombocytopeniatricuspid valve

Identifiers

PMID42292460

DOI10.3389/fimmu.2026.1858060

PMCPMC13254077

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.