Evidence map›Paper›PMID 42292437›Full record

ArticleFrontiers in immunology2026

Adenovirus mediated gene therapy in cell lines derived from canine oral melanoma.

Otavio Augusto Rodrigues, Fernanda Antunes, Gissele Rolemberg Oliveira Silva, Bianca Naomi Niitsuma, Jean Carlos Dos Santos da Luz, Bryan E Strauss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Otavio Augusto Rodrigues *Laboratório de Vetores Virais (LVV), Centro de Investigação Translacional em Oncologia (CTO)/LIM24, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina, Universidade de São Paulo (FMUSP); Comprehensive Center for Precision Oncology (C2PO), Universidade de São Paulo, São Paulo, Brazil.
Fernanda Antunes *Laboratório de Vetores Virais (LVV), Centro de Investigação Translacional em Oncologia (CTO)/LIM24, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina, Universidade de São Paulo (FMUSP); Comprehensive Center for Precision Oncology (C2PO), Universidade de São Paulo, São Paulo, Brazil.
Gissele Rolemberg Oliveira SilvaLaboratório de Vetores Virais (LVV), Centro de Investigação Translacional em Oncologia (CTO)/LIM24, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina, Universidade de São Paulo (FMUSP); Comprehensive Center for Precision Oncology (C2PO), Universidade de São Paulo, São Paulo, Brazil.
Bianca Naomi NiitsumaLaboratório de Vetores Virais (LVV), Centro de Investigação Translacional em Oncologia (CTO)/LIM24, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina, Universidade de São Paulo (FMUSP); Comprehensive Center for Precision Oncology (C2PO), Universidade de São Paulo, São Paulo, Brazil.
Jean Carlos Dos Santos da LuzLaboratório de Vetores Virais (LVV), Centro de Investigação Translacional em Oncologia (CTO)/LIM24, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina, Universidade de São Paulo (FMUSP); Comprehensive Center for Precision Oncology (C2PO), Universidade de São Paulo, São Paulo, Brazil.
Bryan E StraussLaboratório de Vetores Virais (LVV), Centro de Investigação Translacional em Oncologia (CTO)/LIM24, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina, Universidade de São Paulo (FMUSP); Comprehensive Center for Precision Oncology (C2PO), Universidade de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of cancer in dogs can provide valuable insights into the basic biology and the development of novel cancer treatments as veterinary cases develop spontaneously, exhibit heterogeneity and closely match the biology of human cancers. Here we have isolated and characterized cell lines derived from spontaneous oral melanomas from companion dogs and subjected these cells to adenovirus-mediated gene transfer both

Indexed as

AdenoviridaeDog DiseasesGenetic TherapyMelanomaMouth NeoplasmsAnimalsCell Line, TumorDogsGene Therapy AgentsGenetic VectorsHumansInterferon-betaMiceMice, NudeTumor Suppressor Protein p14ARFTumor Suppressor Protein p53Interferon-betaTumor Suppressor Protein p14ARFTumor Suppressor Protein p53adenoviruscomparative oncologygene therapyinterferon-βp53/p14ARF pathwaytranslational research

Identifiers

PMID42292437
PMCPMC13254085

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.