ArticleFrontiers in immunology2026
Integrative single-cell analysis reveals
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
9 authors.
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Abstract
Background: Colorectal cancer (CRC) continues to exhibit a high rate of both incidence and mortality, and most patients respond limitedly to immunotherapy. Increasing evidence suggests that tumor progression is governed by complex interactions between tumor cells (TCs) and the immune microenvironment. However, the multi-layered regulatory mechanisms underlying these interactions remain poorly understood. Methods: Single-cell RNA sequencing profiles sourced from GEO were merged for subsequent integrative analysis. Leveraging Seurat, we carried out data quality filtering, dimensionality reduction, clustering, and cell annotation, while Harmony was applied to correct batch effects. Malignant cells were identified using inferCNV. Functional characteristics were analyzed using various enrichment analyses, and pseudotime analysis was conducted using CytoTRACE, Monocle, and Slingshot. Communication between cells and transcriptional regulatory circuitry were constructed using CellChat and SCENIC. The critical factor Results: The TCs were further classified into six subtypes, among which C4 Conclusion: Overall, we characterized a comprehensive cancer-immune regulatory landscape involving transcriptional programs, intercellular crosstalk, and tumor evolution dynamics. Within this context, a distinct subtype of C4
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