ReviewFrontiers in immunology2026
T cell-microglial interactions that impair myelin maintenance and regeneration: cellular mechanisms on white-matter associated changes.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
White matter changes are a hallmark of aging and neurodegenerative diseases, characterized by progressive myelin deterioration and impaired regenerative capacities. Growing evidence indicates that maladaptive interactions between microglia and infiltrating T lymphocytes contribute to the progression of white matter changes. Recent single-cell and spatial transcriptomic studies have revealed aging-associated shifts in microglial and T cell states, offering new insights into how aging reshapes the immune-glial landscape. This review summarizes the cellular and molecular evidence across species, with emphasis on murine models, showing that aging alters microglial signaling profiles and promotes the recruitment of CD8
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