Evidence map›Paper›PMID 42292350›Full record

ArticleFrontiers in immunology2026

Edyta Paradowska, Katarzyna D Kania, Dariusz Jarych, Damian Mikulski, Elżbieta Jabłonowska, Daria A Haręża, Kamila Wójcik-Cichy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Edyta ParadowskaLaboratory of Virology, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland.
Katarzyna D KaniaLaboratory of Virology, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland.
Dariusz JarychLaboratory of Virology, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland.
Damian MikulskiDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland.
Elżbieta JabłonowskaClinic of Infectious Diseases and Hepatology, Medical University of Lodz, Lodz, Poland.
Daria A HarężaLaboratory of Virology, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland.
Kamila Wójcik-CichyClinic of Infectious Diseases and Hepatology, Medical University of Lodz, Lodz, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: SARS-CoV-2 infection causes an innate immune response that is activated through pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs). Endosomal TLR7/8 detects viral ssRNA, while TLR3 also recognizes dsRNA formed during viral replication. Both RIG-I and MDA5 recognize SARS-CoV-2 RNA in the cytoplasm of infected cells. PRR pathways recruit essential downstream adapter proteins to induce type I interferons (IFNs) and inflammatory cytokines. While genetic variations in host Methods: We genotyped ten Results: In this case-control study, the recessive G/G genotype of the Conclusions: Our findings suggest that the

Indexed as

COVID-19Genetic Predisposition to DiseasePolymorphism, Single NucleotideSARS-CoV-2Toll-Like Receptor 7AdultAgedCytokinesDEAD Box Protein 58FemaleGenotypeHumansInterferon-Induced Helicase, IFIH1MaleMiddle AgedSeverity of Illness IndexCytokinesDEAD Box Protein 58Interferon-Induced Helicase, IFIH1TLR3 protein, humanTLR7 protein, humanToll-Like Receptor 3Toll-Like Receptor 7COVID-19cytokinepolymorphismRLRSARS-CoV-2TLR

Identifiers

PMID42292350
PMCPMC13253635

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.