Evidence map›Paper›PMID 42292342›Full record

ArticleFrontiers in neuroscience2026

The effects of unilateral deprivation amblyopia on fixation stability.

M Nasir, X Chen, B M Stanley, D Maurer, D I Shore, B Thompson, A M F Wong, E Niechwiej-Szwedo

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Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M NasirDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
X ChenDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
B M StanleyDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.
D MaurerDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.
D I ShoreDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.
B ThompsonSchool of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.
A M F WongDepartment of Ophthalmology & Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
E Niechwiej-SzwedoDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Deprivation amblyopia is a neurodevelopmental disorder caused by obstruction of the visual pathway due to congenital cataracts, ptosis or corneal opacities that occur during early visual development. Visual deficits persist into adulthood even though the obstruction (e.g. cataracts) have been removed early in life. The effects of deprivation amblyopia on oculomotor control have not been studied. The present study evaluates the effects of unilateral deprivation amblyopia resulting from congenital cataracts on fixation stability. Method: Seven adults with unilateral deprivation amblyopia and 18 adults with normal vision were tested during binocular and monocular viewing. A video-based eye tracker was used to record eye position of the viewing eye(s) (closed-loop condition with visual feedback) and the covered eye (open-loop condition with no visual feedback). Results: Findings for the control group were consistent with previous studies. Fixation stability (eye position stability), evaluated using bivariate contour ellipse area (BCEA), microsaccade rate, amplitude and slow drift velocity, was best during binocular viewing, and significantly worse during open-loop monocular viewing. In comparison to the control group, patients had similar fellow eye fixation stability under binocular viewing, but fixation (eye position stability) was poorer under monocular closed-loop and open-loop viewing. Fixation stability was worst in the amblyopic eye in all viewing conditions. Discussion: Our findings demonstrate fixation stability deficits in adults with unilateral deprivation amblyopia, underscoring the lasting impact of early visual deprivation on oculomotor function.

Indexed as

BCEAbinoculardeprivation amblyopiamicrosaccademonocular

Identifiers

PMID42292342
PMCPMC13260333

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